New materials: Japan set to come out winner

Centrosome duplication: Three kinases come up a winner!

Despite over one hundred years of research, the duplication of the centrosome is a poorly understood process. Three recent papers--exploring three different kinases--may have provided the answer.

sofosbuvir has come out of the magic box

AKT-ing out: SGK kinases come to the fore.

The success of targeted therapies in treating cancer over the last decade has been tempered by acquired drug resistance that follows long-term treatment. There is also emerging evidence for innate mechanisms of cancer cell resistance to targeted therapy that pre-exist as parallel signalling pathways. This aspect is explored by the Alessi group and collaborators from AstraZeneca in this issue of...

Pediatric Price Transparency: Time to Come Out of the Dark.

You have a child with a high-deductible insurance plan, or a child who lacks insurance completely, who needs a tonsillectomy and adenoidectomy (T&A). How will you know how much this procedure will cost? Considering that more American children are now covered by high-deductible plans, and that there is maddening variation in pricing across hospitals and services, the availability of accurate cos...

Get out! And don't come back!

sing the immune system to attack cancers is a good idea, but it may only work if Toll-like receptors (TLRs) are activated to break tolerance, say Yiping Yang (Duke University, Durham, NC), Drew Pardoll (Johns Hopkins, Baltimore, MD), and colleagues. The favored method for delivering cancer immunotherapy has been dendritic cells: they are the central antigen-presenting cells for generating T cel...